Monday, September 22, 2008
Laquinimod Demonstrated Significant And Sustained Impact On Multiple Sclerosis Disease Activity
New data from the extension phase of oral laquinimod in relapsing-remitting multiple sclerosis (RRMS) demonstrated a significant reduction in the mean number of gadolinium-enhancing (GdE) lesions in both patients who switched from placebo to laquinimod and patients who continued with their initial laquinimod dose. In RRMS patients who switched from placebo to laquinimod, 52 percent reduction in the mean number of GdE lesions was observed (p<0.0007). The reduction was significant for both patients switching to high-dose (p<0.009) and low-dose laquinimod (p<0.03). In addition, the proportion of patients who switched to active treatment from placebo, and remained enhancing lesion-free, increased from 31 percent to 47 percent (p<0.012), further reinforcing the efficacy of laquinimod on magnetic resonance imaging (MRI) measured disease activity.
Friday, September 19, 2008
Neural Cells Derived From Human Embryonic Stem Cells Reduce Multiple Sclerosis (MS) Symptoms
September 08, 2008 08:56 AM Eastern Daylight Time
Hadassah Hospital Study Shows That Neural Cells Derived From Human Embryonic Stem Cells Reduce Multiple Sclerosis (MS) Symptoms
The Study Data Is Published in the Scientific Journal of PLoS
2008 World Stem Cell Summit
EIN KEREM, Israel--(BUSINESS WIRE)--Hadassah University Hospital and Hadasit, the technology transfer company of Hadassah Medical Organization, announced today that scientists at Hadassah University Hospital have discovered a new application for human embryonic stem cells. They have demonstrated for the first time that transplanted neural cells derived from human embryonic stem cells can reduce the clinical symptoms in animals with a form of multiple sclerosis.
The findings of the study are published in an article titled “Neuroprotective Effect of Transplanted Human Embryonic Stem Cell-Derived Neural Precursors in an Animal Model of Multiple Sclerosis” in the Scientific Journal of PLoS One, a new, high-impact, peer-reviewed, open-access, online publication. Click here to access the article: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003145.
The data presented in the report are the result of a long-term collaboration between Professor Tamir Ben Hur, director of the Neurological Department at Hadassah Hospital and Professor Benjamin Reubinoff, director of the Human Embryonic Stem Cell Research Center at Hadassah Hospital. Ms. Michal Aharonowiz and Dr. Ofira Einstein both from Hadassah, as well as Professor Hans Lassmann from the University of Vienna also contributed.
“Human embryonic stem cell-derived neural precursors were transplanted into the brains of mice with an experimental form of MS. The grafted human cells integrated in the mice brains and migrated towards the sites of inflammation. They suppressed the inflammatory process in the brain, and consequently protected the animals from demyelination and nerve cell extension (axonal) injury, which are the pathological hallmarks of MS,” said Professor Benjamin Reubinoff.
Multiple sclerosis, the most common cause of neurological disabilities in young adults, is caused by an inflammatory reaction of the patient’s own immune system against the myelin sheath that envelops the nerve processes. The destruction of myelin leads to the degeneration and loss of nerve cells and permanent neurological disabilities. MS affects 2.5 million people worldwide.
“We believe that the encouraging therapeutic effects in the rodent model of MS justify moving ahead to clinical studies. We also anticipate that the anti-inflammatory effect demonstrated in the pre-clinical study may be combined in the future with the use of other human embryonic stem cell derived neural cells to repair the myelin in the brain,” said Professor Reubinoff.
Hadassah Hospital Study Shows That Neural Cells Derived From Human Embryonic Stem Cells Reduce Multiple Sclerosis (MS) Symptoms
The Study Data Is Published in the Scientific Journal of PLoS
2008 World Stem Cell Summit
EIN KEREM, Israel--(BUSINESS WIRE)--Hadassah University Hospital and Hadasit, the technology transfer company of Hadassah Medical Organization, announced today that scientists at Hadassah University Hospital have discovered a new application for human embryonic stem cells. They have demonstrated for the first time that transplanted neural cells derived from human embryonic stem cells can reduce the clinical symptoms in animals with a form of multiple sclerosis.
The findings of the study are published in an article titled “Neuroprotective Effect of Transplanted Human Embryonic Stem Cell-Derived Neural Precursors in an Animal Model of Multiple Sclerosis” in the Scientific Journal of PLoS One, a new, high-impact, peer-reviewed, open-access, online publication. Click here to access the article: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003145.
The data presented in the report are the result of a long-term collaboration between Professor Tamir Ben Hur, director of the Neurological Department at Hadassah Hospital and Professor Benjamin Reubinoff, director of the Human Embryonic Stem Cell Research Center at Hadassah Hospital. Ms. Michal Aharonowiz and Dr. Ofira Einstein both from Hadassah, as well as Professor Hans Lassmann from the University of Vienna also contributed.
“Human embryonic stem cell-derived neural precursors were transplanted into the brains of mice with an experimental form of MS. The grafted human cells integrated in the mice brains and migrated towards the sites of inflammation. They suppressed the inflammatory process in the brain, and consequently protected the animals from demyelination and nerve cell extension (axonal) injury, which are the pathological hallmarks of MS,” said Professor Benjamin Reubinoff.
Multiple sclerosis, the most common cause of neurological disabilities in young adults, is caused by an inflammatory reaction of the patient’s own immune system against the myelin sheath that envelops the nerve processes. The destruction of myelin leads to the degeneration and loss of nerve cells and permanent neurological disabilities. MS affects 2.5 million people worldwide.
“We believe that the encouraging therapeutic effects in the rodent model of MS justify moving ahead to clinical studies. We also anticipate that the anti-inflammatory effect demonstrated in the pre-clinical study may be combined in the future with the use of other human embryonic stem cell derived neural cells to repair the myelin in the brain,” said Professor Reubinoff.
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